Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.800 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.800 Biomarker disease GENOMICS_ENGLAND Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. 19781682 2009
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.800 GeneticVariation disease UNIPROT
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 Biomarker disease LHGDN Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. 16123218 2005
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 Biomarker disease LHGDN Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity. 16690963 2006
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN We have studied the expression of MIB-1 and prognosis in cyclin D1(CyD1)+ and CyD1- mantle cell lymphoma (MCL), and compared them to B-CLL/SLL. 12002755 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 Biomarker disease LHGDN Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells. 17606765 2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. 17299095 2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN Cyclin Dl expression in B-cell non Hodgkin lymphoma. 17607588 2006
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 Biomarker disease LHGDN In our study, the contribution of each of these mRNAs to gene expression and cell proliferation has been investigated in mantle cell lymphoma (MCL), a B cell lymphoma characterized by a specific gene translocation resulting in enhanced expression of cyclin D1. 15900590 2005
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN The relative levels of cyclin D1a and D1b alternative transcripts in mantle cell lymphoma may depend more on sample origin than on CCND1 polymorphism. 15951302 2005
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN Quantitative monitoring of cyclin D1 expression: a molecular marker for minimal residual disease monitoring and a predictor of the disease outcome in patients with mantle cell lymphoma. 18798551 2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN Quantitative analysis of Cyclin D1 and CD23 expression in mantle cell lymphoma and B-chronic lymphocytic leukemia. 12127555 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 AlteredExpression disease LHGDN Cyclin D1 mRNA isoforms a and b were expressed in mantle cell lymphoma (MCL) and multiple myeloma (MM). 17022831 2006
Entrez Id: 2475
Gene Symbol: MTOR
MTOR 		0.330 Biomarker disease LHGDN Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. 18339899 2008
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.310 AlteredExpression disease LHGDN Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
Entrez Id: 80326
Gene Symbol: WNT10A
WNT10A 		0.310 AlteredExpression disease LHGDN Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
Entrez Id: 7473
Gene Symbol: WNT3
WNT3 		0.310 AlteredExpression disease LHGDN Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B 		0.310 AlteredExpression disease LHGDN Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 Biomarker disease LHGDN Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. 18467333 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		0.100 AlteredExpression disease LHGDN In this study, we investigated the cell signaling pathways activated in bcl-2-overexpressing human mantle cell lymphoma cell lines (JVM-2 and Z-138) that have been treated with oblimersen, a molecular gene silencing strategy that effectively suppresses bcl-2 in vitro and in vivo. 18375822 2008
Entrez Id: 4311
Gene Symbol: MME
MME 		0.090 AlteredExpression disease LHGDN Mantle cell lymphoma with aberrant expression of CD10. 18518902 2008
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.080 Biomarker disease LHGDN Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. 18467333 2008
Entrez Id: 894
Gene Symbol: CCND2
CCND2 		0.080 AlteredExpression disease LHGDN Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas. 18391076 2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.070 PosttranslationalModification disease LHGDN Compared with mantle cell lymphoma, there was more frequent p15 (P=.025) hypermethylation but comparable Rb1 (P=.07) and p16 (P=.07) hypermethylation in follicular lymphoma. 17900658 2007